By Arsenal correspondent Tony Hughes

Arsenal are on alert as Alexis Sanchez is doubtful for Chile’s World Cup qualifier against Uruguay on Tuesday night.

Chile manager Jorge Sampaoli has revealed the attacker has a calf problem and that he will “wait until the last minute” before deciding whether to him in his starting X1.

Sanchez, who was a key figure in Chile’s Copa America triumph last summer, has had an exhausting programme over the last 18 months but has managed to stay injury-free.

Chile will make a late decision on whether to include him as they aim to continue their impressive recent record.

“Alexis has a pain in his calf and we will wait for him until the last minute to see if he is ready to play,” Sampaoli said.

Sanchez has been a virtual ever-present for club and country since the 2014 World Cup and Arsenal are aware they have to handle him carefully to avoid a major breakdown.

The 26-year-old’s fitness is understood to be in the ‘red zone’, the point of fitness at which sportsmen are at a major risk of injury.

Fighting fit: Arsene Wenger and his staff have to manage Sanchez's workload

Fighting fit: Arsene Wenger and his staff have to manage Sanchez’s workload

The Arsenal forward’s condition is a growing concern for Arsene Wenger as the manager plans his team’s title challenge after the international break.

Wenger knows that he has to carefully manage his key player’s workload ahead of a glut of fixtures over the next two months starting with the Premier League trip to West Brom on Saturday.