OPINION By Arsenal correspondent Tony Hughes

Arsene Wenger should not hesitate to ring the changes in the wake of Arsenal’s latest big-match letdown against Manchester United on Sunday.

The Gunners’ failure to overcome what most would agree was the weakest United team ever fielded in the fixture has put a serious dent in their title hopes.

Wenger did not tear into his players after the match – as he did following the midweek defeat to Barcelona – but he will have been alarmed at how the pressure seemed to get to them.

Bar goalkeeper Petr Cech, there appears to be a thread of mental frailty running through the squad and the manager will surely shake things up for the visit of Swansea on Wednesday.

Mohamed Elneny will come into contention for his first Premier League start, while Per Mertesacker, Joel Campbell and Olivier Giroud could all start after being on the bench at Old Trafford.

Two star names who could be facing the axe are Alexis Sanchez and Aaron Ramsey, who epitomise the lack of form of so many of Wenger’s big guns.

Sanchez has been way below par since returning from a hamstring injury over a month ago, while Ramsey has lost the scoring touch that elevates his game from the good to the very good.

Theo Walcott is unlikely to start against Swansea after an anonymous display at Old Trafford, which will mean an instant recall for Giroud.

Arsenal (possible): Cech; Bellerin, Mertesacker, Koscielny, Monreal; Coquelin, Elneny; Campbell, Ozil, Welbeck; Giroud.