By London correspondent Tony Hughes

Eric Dier, Mousa Dembele, Danny Rose and Moussa Sissoko have been ruled out of Tottenham’s Champions League clash against CSKA Moscow on Tuesday.

The senior quartet are all sidelined for the Group E clash in Russia due to injury.

Manager Mauricio Pochettino told the official Tottenham Twitter account on Monday afternoon that Dier, Dembele, Rose, Sissoko and Harry Kane have not travelled with the senior squad to Moscow due to injury.

The absence of the five big guns is a huge blow for Spurs as they aim to ignite their Champions League campaign after an opening-match defeat to Monaco.

Dier, Dembele and Rose missed Saturday’s 2-1 win over Middlesbrough, while Sissoko was substituted in the 70th minute with suspected concussion.

Pochettino had said on Saturday that Dier and Rose were “very close to fitness”, but the Londoners have erred on the side of caution and left the pair in England.

Rose has missed Spurs’ last five matches after suffering a hamstring injury while on international duty earlier this month.

Spurs travelled to Russia on Monday knowing anything but victory will leave them facing an uphill battle in their bid to progress beyond the Champions League group stages.

In other Tottenham team news, Spurs have opened talks over a landmark £31.2million deal.