PREVIEW By North-west correspondent Alex Stevens
Daniel Sturridge has been overlooked as Jurgen Klopp has rung the changes once again for the first Merseyside derby of his Liverpool tenure.
The German manager made 10 changes against Bournemouth at the weekend following the physically and emotionally draining Borussia Dortmund triumph and an experimental team responded with an excellent display and a 2-1 win.
The architect of the triumph on the south coast was Daniel Sturridge, who scored one, assisted the other and looked in finer fettle that at any other point since his return from injury.
But the England international has once again missed out on Wednesday night, with Divock Origi recalled to spearhead the attack in a team featuring nine changes from the weekend.
Origi struggled with a minor back problem in the lead up to the derby but so outstanding were his displays in the two legs of the Europa League tie against Dortmund, he has got the nod over Strurridge and look to extend his run of four goals in three matches.
Klopp has changed the entire back five once again, with first choice quintet Simon Mignolet, Nathaniel Clyne, Dejan Lovren, Mamadou Sakho and Alberto Moreno restored to the starting X1.
With Emre Can joining Jordan Henderson in suffering a serious injury that could rule him out for the rest of the season, Lucas and James Milner have been selected in central midfield.
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Star man Philippe Coutinho has been restored to one of the three attacking midfield slots and the Brazilian is complemented by Roberto Firmino and Adam Lallana.
Liverpool: Mignolet; Clyne, Lovren, Sakho, Moreno; Milner, Lucas; Lallana, Firmino, Coutinho; Origi.