PREVIEW By North-west correspondent Alex Stevens
Jurgen Klopp is set to ring the changes once again as he restores the big hitters for the first Merseyside derby of his Liverpool tenure.
The German manager made 10 changes against Bournemouth at the weekend following the physically and emotionally draining Borussia Dortmund triumph and an experimental team responded with an excellent display and a 2-1 win.
The architect of the triumph on the south coast was Daniel Sturridge, who scored one, assisted the other and looked in finer fettle that at any other point since his return from injury.
Yet the England international could miss out once again on Wednesday unless Klopp springs a surprise and plays both of his leading strikers.
Divock Origi has been struggling with a minor back problem in the lead up to the derby but so outstanding were his displays in the two legs of the Europa League tie against Dortmund, he is likely to once again get the nod over Strurridge and look to extend his run of four goals in three matches.
Klopp could change the entire back five once again, with first choice quintet Simon Mignolet, Nathaniel Clyne, Dejan Lovren, Mamadou Sakho and Alberto Moreno expected to be restored to the starting X1.
With Emre Can joining Jordan Henderson in suffering a serious injury that could rule him out for the rest of the season, Joe Allen can expect to keep his starting role following a series of impressive displays in central midfield.
The Welshman could be joined by James Milner, who was rested at Bournemouth along with nine of the other players who started the remarkable second leg win over Dortmund.
Star man Philippe Coutinho is set to be restored in one of the three attacking midfield slots and the Brazilian could be supplemented by Roberto Firmino and Adam Lallana.
Liverpool (possible): Mignolet; Clyne, Lovren, Sakho, Moreno; Milner, Allen; Lallana, Firmino, Coutinho; Origi.