By London correspondent Tony Hughes

Tottenham could make as many as 10 changes to the starting XI for Tuesday’s EFL Cup clash against Gillingham.

The third-round tie with the League One outfit represents the perfect opportunity for Spurs to rest some first-team stars and unleash the club’s next generation of talent.

Mauricio Pochettino is almost certain to rotate his squad, which will provide opportunities for fringe players and untested youngsters.

Debuts could be handed to centre-back Cameron Carter-Vickers, who has been named in a number of matchday squads without seeing any action, and summer signing Georges-Kevin N’Koudou, who has been building up his fitness after his protracted transfer from Marseille.

Youngsters Harry Winks is likely to be the third Spurs player to be handed a full debut, with the midfielder’s four appearances for the club to date all coming as a substitute.

Fellow youngster Josh Onomah is also in line for a rare start after impressing in various cameos for the senior team.

They are likely to be joined by fringe players Michel Vorm, Ben Davies, Kevin Wimmer, Kieran Trippier, Tom Carroll and Vincent Janssen, who is set for an extended run in the side following the ankle ligament damage suffered by Harry Kane.

There is also likely to be only a second start for headline summer signing Sissoko, who made his full debut in the 1-0 win over Sunderland last Sunday.

Mousa Dembele and Eric Dier suffered hamstring injuries last weekend and are in line to be rested for the clash, allowing Winks and Carroll a chance to shine in front of the home crowd.

Davies, who was omitted against Sunderland on Sunday, and Trippier are likely to step in to the two full-back positions, allowing Kyle Walker to be rested.

There is also likely to be a return for Vorm, played well in the opening three games in the Premier League this season, as Hugo Lloris is one of a number of big guns rested.

In other Tottenham team news, Pochettino has explained why Davies was axed from the starting line up against Sunderland.