Mauricio Pochettino must axe Eric Dier if he wants to start his best possible Tottenham team against Juventus at the Allianz Stadium on Tuesday night.
Spurs return to Champions League action with a testing trip to Italy this week, but Pochettino must make one key change to his 4-2-3-1 formation if he wants to fly back to England with one foot in the quarter finals.
Dier, 24, has been a mainstay for Pochettino this season, but the defensive midfielder should be dropped and replaced by Victor Wanyama in the centre of midfield.
Hugo Lloris must start in goals behind an unchanged back four of Kieran Trippier, Davinson Sanchez, Jan Vertonghen and Ben Davies.
Pochettino is likely to make changes to his full-backs having rotated them for Champions League games in the first half of the season, but if he wants an away goal and win the first leg then he must leave Serge Aurier and Danny Rose on the bench.
The Telegraph has recently reported that Toby Alderweireld has not travelled to Turin to play against Juventus, so it seems as though he will not be able to line up in the rearguard.
Mousa Dembele should be partnered by Wanyama in midfield, instead of Dier.
The England international seems to struggle in the big European fixtures, so leaving him out of this one would make a lot of sense.
In attack, things must remain untouched with Son Heung-min, Dele Alli and Christian Eriksen behind Harry Kane.
In other Tottenham news, this BBC pundit has explained what Levy must do after the win against Arsenal.