Debut for 20-year-old: Three ways Tottenham can line-up in defence v Newcastle after injury update
3-4-2-1: Second chance for Sissoko?
Pochettino used this formation to great success last season, with plenty of other clubs now trialling a three-man defence with pacy wing-backs.
The Argentinian boss is likely to use the formation once again this campaign after using it for much of pre-season, and that could allow a more attacking player to replace Trippier on the right flank.
Step forward Sissoko, who has been in the media spotlight with a move abroad on the cards. However, he could reignite his Spurs career by starring at right wing-back for Spurs.