Youngsters Anthony Ralston, Kristoffer Ajer and Calvin Miller come into the defence while experienced midfielders Stuart Armstrong and Callum McGregor lined up in midfield, along with summer signing Kundai Benyu.
Mikael Lustig, Nir Bitton, Olivier Ntcham, Scott Sinclair and Leigh Griffiths dropped to the bench and Jozo Simunovic did not feature.
Goals from James Forrest and McGregor sealed the win for the visitors as they took their points haul for the new season to nine from three matches.