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8th Sep, 2016 | 2:23pm

Tottenham dealt major blow as senior player ruled out of Stoke clash

By Dominic Toner

Danny Rose will miss the Premier League match against Stoke through injury.

The defender picked up a knock while on international duty with England and Tottenham’s current longest-serving player will be a major loss to the team.

Rose, 26, has a hamstring problem and could also be absent for the club’s opening Champions League group match against Monaco at Wembley on Wednesday.

Mauricio Pochettino confirmed that the injury means he will miss the league clash against Stoke on the club’s Twitter account.

Rose has established himself as a first team regular under Pochettino and formed a settled back-four alongside Toby Alderweireld, Jan Vertonghen and England team-mate Kyle Walker.

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Rose has already made 126 appearances for the North London club, scoring nine goals and supplying 17 assists.

Welshman Ben Davies is likely to replace Rose at left-back. Davies starred at centre-back for Wales at Euro 2016 and helped them reach a surprise semi-final in the competition.

Spurs travel to the Britannia Stadium on Saturday with an unbeaten record to protect in the league, after one win and two draws at the beginning of the campaign.

Braces from Harry Kane and Dele Alli helped them completed a 4-0 victory at Stoke last season and they will be hoping for a repeat performance.

In other Tottenham team news, their midfielder is fighting for his place despite an impressive start.